MRS1220

MRS1220 is an adenosine A3 receptor antagonist (Ki = 0.65 nM for the human receptor). It is selective for human adenosine A3 receptors over rat adenosine A1 and A2receptors (Kis = 305 and 52 nM, respectively). MRS1220 inhibits [35S]GTPgammaS binding in HEK293 cells expressing human adenosine A3 receptors (IC50 = 7.2 nM). In vivo, MRS1220 (0.15 mg/kg) decreases tumor growth and angiogenesis in a rat C6 glioma model.Formal Name: N-[9-chloro-2-(2-furanyl)[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-benzeneacetamide. CAS Number: 183721-15-5. Synonyms: NSC 695674. Molecular Formula: C21H14ClN5O2. Formula Weight: 403.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, Chloroform: Sparingly Soluble: 1-10 mg/ml. SMILES: ClC1=CC(C2=NC(C3=CC=CO3)=NN2C(NC(CC4=CC=CC=C4)=O)=N5)=C5C=C1. InChi Code: InChI=1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28). InChi Key: TWWFAXQOKNBUCR-UHFFFAOYSA-N.