MRK-740

MRK-740 is an inhibitor of the lysine methyltransferase PR/SET domain 9 (PRDM9, IC50 = 80 nM). It inhibits PRDM9-dependent trimethylation of ectopic histone H3K4 (IC50 = 0.8 µM) and endogenous H3K4 in HEK293 cells in a concentration-dependent manner. MRK-740 induces meiotic defects in mouse spermatocytes.Formal Name: 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-1,4,9-triazaspiro[5.5]undecane. CAS Number: 2387510-80-5. Molecular Formula: C25H32N6O3. Formula Weight: 464.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: CC1=CC(N2CCC3(CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)CC2)=CC=N1. InChi Code: InChI=1S/C25H32N6O3/c1-18-13-20(5-8-26-18)30-9-6-25(7-10-30)17-31(12-11-29(25)2)24-27-23(28-34-24)19-14-21(32-3)16-22(15-19)33-4/h5,8,13-16H,6-7,9-12,17H2,1-4H3. InChi Key: NZYTZRHHBAJPKN-UHFFFAOYSA-N.