MPO-IN-28

MPO-IN-28 is an adenosine A2B receptor antagonist (Ki = 2.15 µM in HEK293 cells expressing the human receptor). MPO-IN-28 is also a neuropeptide Y-like receptor 7 (NPYLR7) agonist, inducing calcium mobilization in HEK293T human kidney cells expressing mosquito (A. aegypti) NPYLR7 receptors in a reporter assay when used at a concentration of 10 µM. It inhibits blood-feeding behavior in A. aegypti mosquitos after dietary administration when used at a concentration of 100 µM. MPO-IN-28 also has been used as a synthetic intermediate in the synthesis of Gram-positive bacterial DNA polymerase III inhibitors with antibacterial activity.Formal Name: N-(7-methoxy-4-methyl-2-quinazolinyl)-guanidine. CAS Number: 37836-90-1. Synonyms: MPO Inhibitor 28, Myeloperoxidase Inhibitor 28. Molecular Formula: C11H13N5O. Formula Weight: 231.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble. lambdamax: 250 nm. SMILES: N=C(NC1=NC(C)=C2C=CC(OC)=CC2=N1)N. InChi Code: InChI=1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16). InChi Key: ZJBMSSBTCGJZEE-UHFFFAOYSA-N.