MOZ-IN-3

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 µM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.Formal Name: 4-fluoro-5-methyl-[1,1'-biphenyl]-3-carboxylic acid, 2-(phenylsulfonyl)hydrazide. CAS Number: 2055397-18-5. Synonyms: WM-8014. Molecular Formula: C20H17FN2O3S. Formula Weight: 384.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml, DMSO: 33 mg/ml, Ethanol: 2 mg/ml. SMILES: CC1=C(F)C(C(NNS(C2=CC=CC=C2)(=O)=O)=O)=CC(C3=CC=CC=C3)=C1. InChi Code: InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24). InChi Key: PHHZKBMVRPULAW-UHFFFAOYSA-N.