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Description: MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Target: Chloride channel. Smiles: COc1cc(Nc2ccc(cc2C(O)=O)[N+]([O-])=O)cc2ccccc12. References: TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension[J]. British Journal of Pharmacology, 2019, 176(11).
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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