Mofegiline (hydrochloride)

Mofegiline is an inhibitor of monoamine oxidase B (MAO-B, IC50 = 3.6 nM for the rat brain mitochondrial enzyme). It is selective for MAO-B over MAO-A (IC50 = 680 nM). Mofegiline also inhibits vascular adhesion protein-1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO), an enzyme that has roles in leukocyte adhesion and transmigration, with an IC50 value of 20 nM for the human enzyme. It reduces MPTP-induced decreases in striatal levels of dopamine, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in mice when administered at a dose of 1.25 mg/kg. Mofegiline (5 mg/kg) also inhibits LPS-induced increases in bronchoalveolar lavage fluid (BALF) levels of TNF-alpha in transgenic mice overexpressing VAP-1.Formal Name: 4-fluoro-betaE-(fluoromethylene)-benzenebutanamine, monohydrochloride. CAS Number: 120635-25-8. Synonyms: MDL 72974A. Molecular Formula: C11H13F2N . HCl. Formula Weight: 233.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 30 mg/ml. SMILES: F/C=C(CN)\CCC1=CC=C(C=C1)F.Cl. InChi Code: InChI=1S/C11H13F2N.ClH/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9,/h3-7H,1-2,8,14H2,1H/b10-7+,. InChi Key: QUCNNQHLIHGBIA-HCUGZAAXSA-N.