MNS

MNS is a beta-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Cay-16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively). It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM, respectively) in vitro.Formal Name: 5-(2-nitroethenyl)-1,3-benzodioxole. CAS Number: 1485-00-3. Synonyms: 3,4-Methylenedioxy-beta-nitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III. Molecular Formula: C9H7NO4. Formula Weight: 193.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 0.125 mg/ml. lambdamax: 204, 259, 364 nm. SMILES: O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]. InChi Code: InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+. InChi Key: KFLWBZPSJQPRDD-ONEGZZNKSA-N.