MMP-9/MMP-13 Inhibitor I

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.Formal Name: 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide. CAS Number: 204140-01-2. Synonyms: Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I. Molecular Formula: C25H25N3O6S. Formula Weight: 495.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml. lambdamax: 248 nm. SMILES: O=C(N1CCN(S(C2=CC=C(OC)C=C2)(=O)=O)C(C(NO)=O)C1)C(C=C3)=CC=C3C4=CC=CC=C4. InChi Code: InChI=1S/C25H25N3O6S/c1-34-21-11-13-22(14-12-21)35(32,33)28-16-15-27(17-23(28)24(29)26-31)25(30)20-9-7-19(8-10-20)18-5-3-2-4-6-18/h2-14,23,31H,15-17H2,1H3,(H,26,29). InChi Key: KXZZWRQJKQVMKR-UHFFFAOYSA-N.