MMP-9 Inhibitor I

MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-alpha converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 µM). MMP-9 inhibitor I decreases TNF-alpha secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 µM.Formal Name: 5-[(diethylamino)methyl]-N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-3-methyl-benzamide. CAS Number: 206549-55-5. Synonyms: Matrix Metalloproteinase-9 Inhibitor I. Molecular Formula: C27H33N3O5S. Formula Weight: 511.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/ml. SMILES: CCN(CC)CC1=CC(C)=C(N(S(C2=CC=C(OC)C=C2)(=O)=O)CC3=CC=CC=C3)C(C(NO)=O)=C1. InChi Code: InChI=1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33,34)24-14-12-23(35-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31). InChi Key: WRNMBFWQBKEBIX-UHFFFAOYSA-N.