MMP-2/MMP-9 Inhibitor I

MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 310 and 240 nM, respectively). It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models. This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.Formal Name: N-([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine. CAS Number: 193807-58-8. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor I. Molecular Formula: C21H19NO4S. Formula Weight: 381.4. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml. SMILES: O=S(C(C=C1)=CC=C1C2=CC=CC=C2)(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O. InChi Code: InChI=1S/C21H19NO4S/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,22H,15H2,(H,23,24)/t20-/m1/s1. InChi Key: JBYHBQIDTNHWJF-HXUWFJFHSA-N.