ML221
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated... more
Product information "ML221"
Description: ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 µM in the cAMP assay, and 1.75 µM in the beta-arrestin assay, and EC80 of 10 nM in both assays. Target: Apelin receptor, Arrestin. Smiles: [O-][N+](=O)c1ccc(cc1)C(=O)Oc1coc(CSc2ncccn2)cc1=O. References: Maloney PR, etal. Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 2012 Nov 1,22(21):6656-60.
| Supplier: | TargetMol |
| Supplier-Nr: | T4390 |
Properties
| Application: | Apelin receptor (APJ) antagonist |
| MW: | 385.35 D |
| Formula: | C17H11N3O6S |
Database Information
| CAS : | 877636-42-5| Matching products |
| KEGG ID : | K04174 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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