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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24106-500 | 500 µg | - |
6 - 10 business days* |
133.00€
|
|||
Cay24106-1 | 1 mg | - |
6 - 10 business days* |
225.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical... more
Product information "ML RR-S2 CDA (ammonium salt)"
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA, Cay-17753), indicating the ML enhances its action at human STING. It induces expression of IFN-beta and the pro-inflammatory cytokines TNF-alpha, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-beta expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.Formal Name: [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt. CAS Number: 1638750-96-5. Synonyms: STING Inducer-1. Molecular Formula: C20H22N10O10P2S2 . 2NH4. Formula Weight: 724.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 15 mg/ml, Water: 12.5 mg/ml. SMILES: O[C@@H]([C@H](N1C=NC2=C(N)N=CN=C21)O3)[C@@](O[P@@]4([S-])=O)([H])[C@@]3([H])CO[P@](O[C@@]5([H])[C@H](N6C=NC7=C(N)N=CN=C76)O[C@@]([H])([C@]5(O)[H])CO4)([S-])=O.[NH4+].[NH4+]. InChi Code: InChI=1S/C20H24N10O10P2S2.2H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30,,/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26),2*1H3/t7-,8-,11-,12-,13-,14-,19-,20-,41-,42-,,/m1../s1. InChi Key: VZYXAGGQHVUTHM-ITQXCAEYSA-N.
Keywords: | STING Inducer-1, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24106 |
Properties
Application: | Synthetic cyclic dinucleotide (CDN), STING activator |
MW: | 724.6 D |
Formula: | C20H22N10O10P2S2 . 2NH4 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 1638750-96-5| Matching products |
KEGG ID : | K12654 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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