ML RR-S2 CDA (ammonium salt)

ML RR-S2 CDA (ammonium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24106-500 500 µg -

6 - 10 business days*

133.00€
Cay24106-1 1 mg -

6 - 10 business days*

225.00€
 
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical... more
Product information "ML RR-S2 CDA (ammonium salt)"
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA, Cay-17753), indicating the ML enhances its action at human STING. It induces expression of IFN-beta and the pro-inflammatory cytokines TNF-alpha, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-beta expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.Formal Name: [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt. CAS Number: 1638750-96-5. Synonyms: STING Inducer-1. Molecular Formula: C20H22N10O10P2S2 . 2NH4. Formula Weight: 724.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 15 mg/ml, Water: 12.5 mg/ml. SMILES: O[C@@H]([C@H](N1C=NC2=C(N)N=CN=C21)O3)[C@@](O[P@@]4([S-])=O)([H])[C@@]3([H])CO[P@](O[C@@]5([H])[C@H](N6C=NC7=C(N)N=CN=C76)O[C@@]([H])([C@]5(O)[H])CO4)([S-])=O.[NH4+].[NH4+]. InChi Code: InChI=1S/C20H24N10O10P2S2.2H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30,,/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26),2*1H3/t7-,8-,11-,12-,13-,14-,19-,20-,41-,42-,,/m1../s1. InChi Key: VZYXAGGQHVUTHM-ITQXCAEYSA-N.
Keywords: STING Inducer-1, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'->5')-adenosine, cyclic nucleotide, diammonium salt
Supplier: Cayman Chemical
Supplier-Nr: 24106

Properties

Application: Synthetic cyclic dinucleotide (CDN), STING activator
MW: 724.6 D
Formula: C20H22N10O10P2S2 . 2NH4
Purity: >98%
Format: Solid

Database Information

CAS : 1638750-96-5| Matching products
KEGG ID : K12654 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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