ML-792

ML-792 is an inhibitor of SUMO-activating enzyme (SAE, IC50s = 0.003 and 0.011 µM with small ubiquitin-related modifier 1 (SUMO-1) or SUMO-2, respectively, as the ubiquitin-like proteins). It is selective for SAE over NEDD8-activating enzyme (NAE) and ubiquitin-activating enzyme (UAE, IC50s = 32 and >100 µM, respectively). ML-792 inhibits SAE activity and decreases global SUMOylation in HCT116 human colon cancer cells (EC50 = 0.019 µM), as well as decreases the viability of MDA-MB-468 human breast and A375 human melanoma cells (EC50s = 0.06 and 0.45 µM, respectively). It also induces mitotic defects in HCT116 cells and impairs chromosomal segregation in HCT116, A375, and COLO 205 cells. ML-792 reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 150 and 200 mg/kg twice per day.Formal Name: sulfamic acid, [(1R,2S,4R)-4-[[5-[[1-[(3-bromophenyl)methyl]-1H-pyrazol-3-yl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester. CAS Number: 1644342-14-2. Molecular Formula: C21H23BrN6O5S. Formula Weight: 551.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 213, 265 nm. SMILES: O[C@@H]1[C@@H](COS(N)(=O)=O)C[C@@H](NC2=NC=NC=C2C(C3=NN(CC4=CC(Br)=CC=C4)C=C3)=O)C1. InChi Code: InChI=1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,10-11H2,(H2,23,31,32)(H,24,25,26)/t14-,16-,19+/m1/s1. InChi Key: PZCKLTWSXFDLLP-OGWOLHLISA-N.