ML-417

ML-417 is a dopamine D3 receptor agonist. It is selective for the dopamine D3 receptor over the dopamine D2 receptor (EC50s = 38 and >10,000 nM, respectively, in beta-arrestin recruitment assays using CHO-K1 cells expressing the human receptors) and dopamine D1, D4, and D5 receptors, as well as a panel of 45 G protein-coupled receptors (GPCRs), transporters, and ion channels at 10 µM. ML-417 inhibits forskolin-induced cAMP accumulation in HEK293 cells expressing the human dopamine D3 receptor (IC50 = 86 nM) and induces phosphorylation of ERK in CHO-K1 cells expressing the human dopamine D3 receptor (EC50 = 21 nM). It protects against cell death induced by the catecholaminergic neurotoxin 6-OHDA (Cay-25330) in human induced pluripotent stem cell-derived (iPSC-derived) cells differentiated into dopaminergic neurons when used at a concentration of 50 nM.Formal Name: 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-methanone. CAS Number: 1386162-69-1. Molecular Formula: C22H25N3O3. Formula Weight: 379.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Soluble. lambdamax: 218, 294 nm. SMILES: O=C(N1CCN(CC1)CCOC2=CC=C(C=C2)OC)C3=CC4=C(N3)C=CC=C4. InChi Code: InChI=1S/C22H25N3O3/c1-27-18-6-8-19(9-7-18)28-15-14-24-10-12-25(13-11-24)22(26)21-16-17-4-2-3-5-20(17)23-21/h2-9,16,23H,10-15H2,1H3. InChi Key: HAZPAMUWUHDPDA-UHFFFAOYSA-N.