ML-348

Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas. Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling. ML-348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).Formal Name: N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide. CAS Number: 899713-86-1. Synonyms: CID-3238952, SID 160654487. Molecular Formula: C18H17ClF3N3O3. Formula Weight: 415.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 248 nm. SMILES: O=C(NC1=C(Cl)C=CC(C(F)(F)F)=C1)CN2CCN(C(C3=CC=CO3)=O)CC2. InChi Code: InChI=1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26). InChi Key: OXKNHBBDOIMFFQ-UHFFFAOYSA-N.