ML-329

ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 µM for promoter activity of the MITF target gene TRPM-1. It is selectively cytotoxic to the SK-MEL-5 and MALME-3M MITF-dependent melanoma cell lines over A375 MITF-independent cells (IC50s = 0.1, 0.7, and 70 µM, respectively).Formal Name: 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide. CAS Number: 19992-50-8. Molecular Formula: C16H12N2O4S. Formula Weight: 328.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 202, 281, 455 nm. SMILES: O=C1C(NC2=CC=C(S(N)(=O)=O)C=C2)=CC(C3=CC=CC=C31)=O. InChi Code: InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22). InChi Key: CSYFFQVEQXEIAB-UHFFFAOYSA-N.