ML-184

GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI). ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCbetaII to the plasma membrane by activating GPR55.Formal Name: 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-benzenesulfonamide. CAS Number: 794572-10-4. Synonyms: CID-2440433. Molecular Formula: C25H34N4O3S. Formula Weight: 470.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 210, 290 nm. SMILES: CC1=CC=CC(N2CCN(C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)CC2)=C1C. InChi Code: InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3. InChi Key: VRSJAHQGJHDACS-UHFFFAOYSA-N.