ML-137

ML-137 is a positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptors (mAChRs). It is selective for M1 over M2-M5 mAChRs at 30 µM. ML-137 potentiates ACh-induced activation of the M1 muscarinic receptor (EC50 = 0.83 µM).Formal Name: 1-[[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-1H-indole-2,3-dione. CAS Number: 1222834-53-8. Synonyms: VU0366369. Molecular Formula: C19H14FN3O2. Formula Weight: 335.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml. SMILES: FC1=CC(C2=CN(C)N=C2)=CC=C1CN3C(C(C4=C3C=CC=C4)=O)=O. InChi Code: InChI=1S/C19H14FN3O2/c1-22-10-14(9-21-22)12-6-7-13(16(20)8-12)11-23-17-5-3-2-4-15(17)18(24)19(23)25/h2-10H,11H2,1H3. InChi Key: JCOKRGWZMBZKFO-UHFFFAOYSA-N.