MK-8722

MK-8722 is an activator of AMP-activated protein kinase (AMPK). It activates Ampk and increases phosphorylated acetyl-CoA carboxylase 1 (Acc1) levels in primary mouse dorsal root ganglia (DRG) when used at concentrations of 0.1 and 10 µM. MK-8722 (20 and 50 µM) reduces the proliferation, colony formation, migration, and invasion of, and induces apoptosis in, PANC-1 and PaTu 8988 pancreatic cancer cells. It induces cell cycle arrest at the G2 phase in PANC-1 and PaTu 8988 cancer cells when used at a concentration of 50 µM. In vivo, MK-8722 (25 mg/kg per day) reduces tumor volume and weight in a PANC-1 mouse xenograft model. It decreases blood glucose levels in fasting and glucose-challenged mice in a mouse model of diabetes induced by a high-fat diet when administered at doses of 10 and 30 mg/kg. MK-8722 (30 mg/kg) increases the paw withdrawal threshold in the von Frey test in mice.Formal Name: 1,4:3,6-dianhydro-2-O-(5-[1,1'-biphenyl]-4-yl-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-D-mannitol. CAS Number: 1394371-71-1. Molecular Formula: C24H20ClN3O4. Formula Weight: 449.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: Slightly soluble. SMILES: ClC1=C(C2=CC=C(C3=CC=CC=C3)C=C2)N=C(C(N4)=C1)N=C4O[C@H]5[C@]6([H])[C@]([C@@H](CO6)O)([H])OC5. InChi Code: InChI=1S/C24H20ClN3O4/c25-16-10-17-23(28-24(26-17)32-19-12-31-21-18(29)11-30-22(19)21)27-20(16)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-10,18-19,21-22,29H,11-12H2,(H,26,27,28)/t18-,19-,21-,22-/m1/s1. InChi Key: XQMNBTZLYOOAGA-UGESXGAOSA-N.