(-)-MK-801 (maleate)

(-)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Cay-10009019). In vivo, (-)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg). (-)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity. (-)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 µM for electric eel and rat brain AChE, respectively.Formal Name: (5R,10S)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate. CAS Number: 121917-57-5. Molecular Formula: C16H15N . C4H4O4. Formula Weight: 337.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. SMILES: [H][C@]12CC3=C(C=CC=C3)[C@](N2)(C)C4=CC=CC=C41.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16,5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3,1-2H,(H,5,6)(H,7,8)/b,2-1-/t15-,16+,/m0./s1. InChi Key: QLTXKCWMEZIHBJ-FWHYOZOBSA-N.