MIV-150

MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro). It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors. Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.Formal Name: N-(5-cyano-2-pyridinyl)-N-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]-urea. CAS Number: 231957-54-3. Synonyms: PC-815. Molecular Formula: C19H17FN4O3. Formula Weight: 368.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 210, 262 nm. SMILES: FC1=C([C@H]2[C@@H](NC(NC3=NC=C(C#N)C=C3)=O)C2)C(O)=C(C(CC)=O)C=C1. InChi Code: InChI=1S/C19H17FN4O3/c1-2-15(25)11-4-5-13(20)17(18(11)26)12-7-14(12)23-19(27)24-16-6-3-10(8-21)9-22-16/h3-6,9,12,14,26H,2,7H2,1H3,(H2,22,23,24,27)/t12-,14+/m1/s1. InChi Key: NKPHEWJJTGPRSL-OCCSQVGLSA-N.