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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29414-1 | 1 mg | - |
6 - 10 business days* |
415.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mitoxantrone-d8 is intended for use as an internal standard for the quantification of... more
Product information "Mitoxantrone-d8"
Mitoxantrone-d8 is intended for use as an internal standard for the quantification of mitoxantrone (Cay-14842) by GC- or LC-MS. Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner. Mitoxantrone inhibits the growth of K562 leukemia and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively). It also inhibits the membrane fusion of a mixed population of HEK293T cells expressing either angiotensin-converting enzyme 2 (ACE2) or the extracellular domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein. Mitoxantrone (0.2 µM) inhibits the entry of SARS-CoV-2 into Vero E6 cells. Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.Formal Name: 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl-1,1,2,2-d4)amino]ethyl]amino]-9,10-anthracenedione. CAS Number: 1189974-82-0. Molecular Formula: C22H20D8N4O6. Formula Weight: 452.5. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C1C2=C(C(O)=CC=C2O)C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O. InChi Code: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2/i9D2,10D2,11D2,12D2. InChi Key: KKZJGLLVHKMTCM-PMCMNDOISA-N.
Keywords: | 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl-1,1,2,2-d4)amino]ethyl]amino]-9,10-anthracenedione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29414 |
Properties
Application: | GC-MS, LC-MS, internal standard, topoisomerase II inhibitor, HIV-1 integrase inhibitor |
MW: | 452.5 D |
Formula: | C22H20D8N4O6 |
Purity: | >99% deuterated forms (d1-d8) |
Format: | Solid |
Database Information
CAS : | 1189974-82-0| Matching products |
KEGG ID : | K03164 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H340, H351 |
P Phrases: | P201, P202, P280, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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