Mirogabalin

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the alpha2delta-1 and alpha2delta-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ, Cay-13104). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose.Formal Name: (1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo[3.2.0]hept-3-ene-6-acetic acid. CAS Number: 1138245-13-2. Synonyms: DS-5565. Molecular Formula: C12H19NO2. Formula Weight: 209.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.5 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: CCC1=C[C@]([C@](CC(O)=O)(CN)C2)([H])[C@]2([H])C1. InChi Code: InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1. InChi Key: FTBQORVNHOIASH-CKYFFXLPSA-N.