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![Miltefosine-d4](https://www.biomol.com/media/image/06/d9/12/Cay34707-1_600x600.png)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Miltefosine-d4 is intended for use as an internal standard for the quantification of miltefosine... more
Product information "Miltefosine-d4"
Miltefosine-d4 is intended for use as an internal standard for the quantification of miltefosine (Cay-63280) by GC- or LC-MS. Miltefosine is an inhibitor of CTP:phosphocholine cytidylyltransferase (CCT). It inhibits liposome-induced CCT activity in MDCK cell homogenates when used at concentrations ranging from 10 to 50 µM, as well as induces translocation of CCT from the cell membrane to the cytosol in MDCK cells. Miltefosine inhibits phosphatidylcholine biosynthesis induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in MDCK and HeLa cells when used at a concentration of 50 µM. It inhibits phosphatidylserine-activated PKC (IC50 = 62 µM), as well as PMA-induced morphological changes and proliferation of MDCK cells. Miltefosine is active against clinical isolate promastigotes of L. infantum (EC50s = 5-25 µM). Topical application of miltefosine (0.5%) completely eradicates L. amazonensis and induces re-epithelialization of lesions in a mouse model of cutaneous leishmaniasis. Formulations containing miltefosine have been used in the treatment of leishmaniasis and various free-living amoeba infections.Formal Name: 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium-1,1,2,2-d4, inner salt. Synonyms: Hexadecylphosphocholine-d4, HPC-d4. Molecular Formula: C21H42D4NO4P. Formula Weight: 411.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble, Water: soluble. SMILES: CCCCCCCCCCCCCCCCOP(OC([2H])([2H])C([2H])([2H])[N+](C)(C)C)([O-])=O. InChi Code: InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3/i19D2,21D2. InChi Key: PQLXHQMOHUQAKB-KQHQIZQISA-N.
Keywords: | Hexadecylphosphocholine-d4, HPC-d4, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium-1,1,2,2-d4, inner salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 34707 |
Properties
Application: | GC-MS, LC-MS internal standard, Quantification, CTP inhibitor |
MW: | 411.6 D |
Formula: | C21H42D4NO4P |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
KEGG ID : | K00968 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H334, H361, H372 |
P Phrases: | P201, P202, P260, P261, P264, P270, P280, P284, P304+341, P308+313, P314, P342+311, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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