MI-2 [MALT1 Inhibitor]

White to off-white solid. Soluble in DMSO (30mg/ml) or ethanol (5mg/ml). Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8&mu,M). Binds directly to MALT1 and suppresses protease function, Decreases NF-kappaB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo, In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells, Inhibits NF-kappaB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1beta/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.