Metyrapone

Metyrapone
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14994-250 250 mg -

6 - 10 business days*

34.00€
Cay14994-500 500 mg -

6 - 10 business days*

58.00€
Cay14994-1 1 g -

6 - 10 business days*

102.00€
 
Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83... more
Product information "Metyrapone"
Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis. It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in sheep liver microsomes. Metyrapone (150 mg/kg, s.c.) suppresses hypoxia-ischemia-induced increases in plasma corticosterone levels and seizures in rats. It also reduces ethanol consumption in alcohol high-preferring rats. Formulations containing metyrapone have been used in the diagnosis of adrenal insufficiency and the treatment of Cushing's disease.Formal Name: 2-methyl-1,2-di-3-pyridinyl-1-propanone. CAS Number: 54-36-4. Synonyms: NSC 25265, SU 4885. Molecular Formula: C14H14N2O. Formula Weight: 226.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 231, 264 nm. SMILES: O=C(C1=CN=CC=C1)C(C)(C)C2=CC=CN=C2. InChi Code: InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3. InChi Key: FJLBFSROUSIWMA-UHFFFAOYSA-N.
Keywords: NSC 25265, SU 4885, 2-methyl-1,2-di-3-pyridinyl-1-propanone
Supplier: Cayman Chemical
Supplier-Nr: 14994

Properties

Application: 11beta-hydroxylase inhibitor, CYP450 inhibitor
MW: 226.3 D
Formula: C14H14N2O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 54-36-4| Matching products
KEGG ID : K00497 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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