Metkephamid acetate

Description: Metkephamid acetate is a synthetic opioid pentapeptide and derivative of [Met]enkephalin. It shows as a potent agonist of the delta- and µ-opioid receptors with roughly equipotent affinity, and also has similarly high affinity as well as subtype-selectivity for the kappa3-opioid receptor. Target: Others. Smiles: CC(O)=O.CSCC[C@H](N(C)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O. References: Burkhardt C, Frederickson RC, Pasternak GW. Metkephamid (Tyr-D-ala-Gly-Phe-N(Me)Met-NH2), a potent opioid peptide: receptor binding and analgesic properties. Peptides. 1982 Sep-Oct,3(5):869-71. PubMed PMID: 6294639.