Metixene (hydrochloride hydrate)

Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the proliferation of P388 leukemia and doxorubicin-resistant P388 (P388/ADR) cells (EC50s = 10 and 12 µM, respectively). It induces apoptosis in BT474 and MDA-MB-231 breast cancer cells when used at a concentration of 15 µM and induces autophagy in the same cells at 10 µM. In vivo, metixene (1 mg/kg three times per week) decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model.Formal Name: 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate. CAS Number: 7081-40-5. Synonyms: Methixine. Molecular Formula: C20H23NS . HCl [H2O]. Formula Weight: 363.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: :, Water: Soluble. SMILES: CN1CCCC(CC2C3=C(C=CC=C3)SC4=C2C=CC=C4)C1.Cl.O. InChi Code: InChI=1S/C20H23NS.ClH.H2O/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20,,/h2-5,8-11,15,18H,6-7,12-14H2,1H3,1H,1H2. InChi Key: RAOHHYUBMJLHNC-UHFFFAOYSA-N.