Methyllycaconitine (citrate)

Methyllycaconitine (MLA) is an antagonist of alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs, Ki = 1.4 nM). It is less effective at other nAChRs. MLA is used to selectively evaluate the role of alpha7-containing nAChRs in signaling pathways.Formal Name: 20-ethyl-1alpha,6beta,14alpha,16beta-tetramethoxy-4-[[[2-[(3S)-3-methyl-2,5-dioxo-1-pyrrolidinyl]benzoyl]oxy]methyl]-aconitane-7,8-diol, 2-hydroxy-1,2,3-propanetricarboxylate. CAS Number: 351344-10-0. Synonyms: MLA. Molecular Formula: C37H50N2O10 . C6H8O7. Formula Weight: 874.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: CCN1C[C@]2(COC(C3=C(N4C(C[C@H](C)C4=O)=O)C=CC=C3)=O)CC[C@H](OC)[C@]56[C@]2([H])[C@H](OC)[C@]([C@@H]16)(O)[C@](C[C@H](OC)[C@@]([H])(C7)[C@@H]8OC)(O)[C@]8([H])[C@]57[H].OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36,7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33. InChi Key: INBLZNJHDLEWPS-OULUNZSJSA-N.