Methyclothiazide

Methylclothiazide is a thiazide diuretic. It inhibits norepinephrine- (Cay-16673) and vasopressin-induced contractions of aortic rings isolated from spontaneously hypertensive rats at a concentration of 100 µM. Methylclothiazide reduces salt-induced increases in blood pressure in salt-sensitive but not salt-resistant rats without affecting body weight or heart rate. Formulations containing methylclothiazide have been used to treat hypertension.Formal Name: 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 135-07-9. Synonyms: NSC 110431. Molecular Formula: C9H11Cl2N3O4S2. Formula Weight: 360.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: ClC1=C(S(N)(=O)=O)C=C(S(N(C)C(CCl)N2)(=O)=O)C2=C1. InChi Code: InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16). InChi Key: CESYKOGBSMNBPD-UHFFFAOYSA-N.