Methotrexate
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate... more
Product information "Methotrexate"
Description: Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors. Target: DNA/RNA Synthesis, Dehydrogenase, Apoptosis, ADC Cytotoxin, Antifolate. Smiles: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1. References: Norris RE, et al. Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May,65(6):1125-30.
| Keywords: | Amethopterin, CL14377, NCI-C04671, WR19039 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1485 |
Properties
| Application: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| MW: | 454.44 D |
| Formula: | C20H22N8O5 |
Database Information
| CAS : | 59-05-2| Matching products |
| KEGG ID : | K00287 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H315, H319, H360 |
| P Phrases: | P201, P202, P264, P270, P280, P321, P330, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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