Methocarbamol-d5

Methocarbamol-d5 is intended for use as an internal standard for the quantification of methocarbamol (Cay-23870) by GC- or LC-MS. Methocarbamol is an orally bioavailable skeletal muscle relaxant. In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg. It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg. Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 µM, respectively). Formulations containing methocarbamol have been used to treat skeletal muscle spasms.Formal Name: 3-(2-methoxyphenoxy)-1,2-propane-1,1,2,3,3-d5-diol, 1-carbamate. CAS Number: 1189699-70-4. Synonyms: AHR 85-d5, Guaiacol Glyceryl Ether Carbamate-d5, Guaiphenesin Carbamate-d5. Molecular Formula: C11H10D5NO5. Formula Weight: 246.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: NC(OC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=C(C=CC=C1)OC)=O. InChi Code: InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)/i6D2,7D2,8D. InChi Key: GNXFOGHNGIVQEH-RORPNYJOSA-N.