Methiothepin (maleate)

Methiothepin (maleate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay23138-10 10 mg - -

6 - 10 business days*

44.00€
Cay23138-25 25 mg - -

6 - 10 business days*

96.00€
Cay23138-50 50 mg - -

6 - 10 business days*

137.00€
Cay23138-100 100 mg - -

6 - 10 business days*

252.00€
 
Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor. It is a potent... more
Product information "Methiothepin (maleate)"
Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor. It is a potent antagonist of 5-HT1A and 5-HT1B (IC50 = 16 nM and Ki = 0.2 nM, respectively) as well as 5-HT2A, 5-HT2B, and 5-HT2C receptors (Kis = 3.16, 2.08, and 4.46 nM, respectively). Methiothepin binds to 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7 receptors with Kd values of 100, 15.8, 1.8, and 1 nM, respectively. It has been used to characterize the role of serotonin in various biological processes, including renal vasodilation and gastrointestinal function.Formal Name: 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-piperazine, (2Z)-butenedioate. CAS Number: 19728-88-2. Synonyms: Metitepine. Molecular Formula: C20H24N2S2 . C4H4O4. Formula Weight: 472.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 276 nm. SMILES: CN(CC1)CCN1C2C3=C(C=CC(SC)=C3)SC4=CC=CC=C4C2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20,5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: IWDBEHWZGDSFHR-BTJKTKAUSA-N.
Keywords: Metitepine, 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-piperazine, (2Z)-butenedioate
Supplier: Cayman Chemical
Supplier-Nr: 23138

Properties

Application: 5-HT2 / 5-HT1 antagonist
MW: 472.6 D
Formula: C20H24N2S2 . C4H4O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 19728-88-2| Matching products
KEGG ID : K04153 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H311, H331, H402
P Phrases: P261, P264, P270, P271, P273, P280, P311, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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