Methiocarb-d3

Methiocarb-d3 is intended for use as an internal standard for the quantification of methiocarb (Cay-25627) by GC- or LC-MS. Methiocarb is a carbamate pesticide. It inhibits the activity of acetylcholinesterase (AChE) from methiocarb-resistant and -sensitive western flower thrips (F. occidentalis, IC50s = 0.43 and 2.1 µM, respectively) and is toxic to the same strains (LC50s = 31.1 and 3.26 ppm for the resistant- and sensitive strains, respectively). Methiocarb is also toxic to the land snail (M. obstructa, LD50 = 27.4 µg/animal) and induces 94% mortality in citrus mites (A. pelekassi) when used at a concentration of 0.5 ppm. It is an estrogen receptor alpha (ERalpha) and ERbeta agonist (EC20s = 19.87 and 20.24 µM, respectively) and androgen receptor antagonist (IC50 = 13.89 µM) in cell-based reporter assays. It is toxic to juvenile rainbow trout and guppies with LC50 values of 0.795 and 1.482 mg/L, respectively, at 48 hours of exposure. Formulations containing methiocarb have been used in the control of mollusks, mites, and insects in residential and commercial settings.Formal Name: 3,5-dimethyl-4-(methylthio)phenyl (methyl-d3)carbamate. CAS Number: 1581694-94-1. Synonyms: Mercaptodimethur-d3, 4-Methylthio-3,5-dimethylphenyl methylcarbamate-d3. Molecular Formula: C11H12D3NO2S. Formula Weight: 228.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C(NC([2H])([2H])[2H])OC1=CC(C)=C(SC)C(C)=C1. InChi Code: InChI=1S/C11H15NO2S/c1-7-5-9(14-11(13)12-3)6-8(2)10(7)15-4/h5-6H,1-4H3,(H,12,13)/i3D3. InChi Key: YFBPRJGDJKVWAH-HPRDVNIFSA-N.