Methimazole-d3

Methimazole-d3 is intended for use as an internal standard for the quantification of methimazole (Cay-23718) by GC- or LC-MS. Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%. It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.Formal Name: 1,3-dihydro-1-(methyl-d3)-2H-imidazole-2-thione. CAS Number: 1160932-07-9. Molecular Formula: C4H3D3N2S. Formula Weight: 117.2. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: S=C1NC=CN1C([2H])([2H])[2H]. InChi Code: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)/i1D3. InChi Key: PMRYVIKBURPHAH-FIBGUPNXSA-N.