Metergoline

Description: Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPT INE as a dopamine agonist and also for migraine disorder therapy. Target: 5-HT Receptor, Sodium Channel, Dopamine Receptor. Smiles: CN1C2=C3C([C@@]4([C@@](CC3=C1)(N(C)C[C@H](CNC(OCC5=CC=CC=C5)=O)C4)[H])[H])=CC=C2. References: Millan, M.J.,Newman-Tancredi, A.,Lochon, S., et al. Specific labelling of serotonin 5-HT1B receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacol. Biochem. Behav. 71(4), 589-598 (2002).