Mertansine
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1... more
Product information "Mertansine"
Description: Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. Target: Microtubule Associated, ADC Cytotoxin. Smiles: CO[C@@H]1\C=C/C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCS)[C@@]2(C)O[C@H]2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2. References: Whiteman KR, et al. MAbs. 2014 Mar-Apr,6(2): 556-66.
| Keywords: | DM1, Maytansinoid DM1 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1992 |
Properties
| Application: | Maytansinoid tubulin inhibitor |
| MW: | 738.29 D |
| Formula: | C35H48ClN3O10S |
Database Information
| CAS : | 139504-50-0| Matching products |
| KEGG ID : | K07374 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300, H310, H314, H340, H360, H370 |
| P Phrases: | P201, P202, P260, P262, P264, P270, P280, P301+310, P301+330+331, P302+352, P303+361+353, P304+340, P305+351+338, P308+311, P308+313, P310, P321, P330, P361+364, P363, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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