Meropenem (hydrate)

Meropenem is a carbapenem antibiotic. It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = =0.008-8 µg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively. Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.Formal Name: (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, trihydrate. CAS Number: 119478-56-7. Synonyms: ICI 194660, SM-7338. Molecular Formula: C17H25N3O5S . 3H2O. Formula Weight: 437.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 306 nm. SMILES: O=C(O)C1=C(S[C@@H]2CN[C@H](C(N(C)C)=O)C2)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O.O.O.O. InChi Code: InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4,,,/h7-12,18,21H,5-6H2,1-4H3,(H,24,25),3*1H2/t7-,8-,9+,10+,11-,12-,,,/m1.../s1. InChi Key: CTUAQTBUVLKNDJ-OBZXMJSBSA-N.