Meropenem-d6

Meropenem-d6 is intended for use as an internal standard for the quantification of meropenem (Cay-16068) by GC- or LC-MS. Meropenem is a carbapenem antibiotic. It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = =0.008-8 µg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively. Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.Formal Name: (4R,5S,6S)-rel-3-[[(3S,5S)-5-[[di(methyl-d3)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. CAS Number: 1217976-95-8. Molecular Formula: C17H19D6N3O5S. Formula Weight: 389.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Methanol: slightly soluble. SMILES: O=C(O)C1=C(S[C@@H]2CN[C@H](C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C2)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O. InChi Code: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1/i3D3,4D3. InChi Key: DMJNNHOOLUXYBV-ZSJYILIPSA-N.