Merimepodib

Merimepodib is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH, Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells (EC50 = 0.6 µM). Merimepodib inhibits the proliferation of PHA-stimulated T cells and SPAS-stimulated B cells (IC50s = 104 and 132 nM, respectively), effects that can be reversed by guanosine (Cay-27702) but not adenosine (Cay-21232). In vivo, merimepodib (50 and 100 mg/kg) increases allograft survival in a murine skin transplantation model and prevents development of graft versus host disease (GVHD) in splenocyte allografted mice.Formal Name: N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester. CAS Number: 198821-22-6. Synonyms: VX-497. Molecular Formula: C23H24N4O6. Formula Weight: 452.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 228, 287, 309, 320 nm. SMILES: COC1=C(C2=CN=CO2)C=CC(NC(NC3=CC(CNC(O[C@H]4CCOC4)=O)=CC=C3)=O)=C1. InChi Code: InChI=1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1. InChi Key: JBPUGFODGPKTDW-SFHVURJKSA-N.