Merestinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Merestinib (LY2801653) is an orally available, small molecule inhibitor of the... more
Product information "Merestinib"
Description: Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein. Target: Discoidin Domain Receptor (DDR), c-Met/HGFR, ROS Kinase, ROS, FLT. Smiles: O(C1=C(C=C2C(=C1)C=NN2C)C=3C=NNC3)C4=C(F)C=C(NC(=O)C=5C(=O)N(C(C)=CC5)C6=CC=C(F)C=C6)C=C4. References: Yan SB, et al. Invest New Drugs. 2013, 31(4):833-44.
| Keywords: | LY2801653 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3455 |
Properties
| Application: | Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR) |
| MW: | 552.53 D |
| Formula: | C30H22F2N6O3 |
Database Information
| CAS : | 1206799-15-6| Matching products |
| KEGG ID : | K04372 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H351, H360, H372 |
| P Phrases: | P201, P202, P260, P264, P270, P280, P314, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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