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![Melagatran](https://www.biomol.com/media/image/4c/f3/01/Cay9002300-2_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay9002300-2 | 2 mg | - |
6 - 10 business days* |
715.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Melagatran is an inhibitor of thrombin (Ki = 0.002 µM) and an active metabolite of the prodrug... more
Product information "Melagatran"
Melagatran is an inhibitor of thrombin (Ki = 0.002 µM) and an active metabolite of the prodrug ximelagatran (Cay-16862). It is selective for thrombin over a variety of serine proteases (Kis = 0.6-10.2 µM) but also inhibits trypsin (Ki = 0.004 µM). Melagatran inhibits thrombin-induced aggregation of isolated washed human platelets (IC50 = 1.9 nM). It decreases the dry weight of thrombi in rats (ED50 = 16 µg/kg). Melagatran increases total bleeding time and blood loss in rats (ID50s = 300 and 6.8 µg/kg, respectively). Melagatran (5 µmol/kg per hour), alone or in combination with tissue plasminogen activator (tPA), reduces brain infarct volume and increases blood reperfusion in a rat model of ischemia-induced traumatic brain injury (TBI).Formal Name: N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-glycine. CAS Number: 159776-70-2. Molecular Formula: C22H31N5O4. Formula Weight: 429.5. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: NC(C1=CC=C(CNC([C@@H]2CCN2C([C@@H](C3CCCCC3)NCC(O)=O)=O)=O)C=C1)=N. InChi Code: InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1. InChi Key: DKWNMCUOEDMMIN-PKOBYXMFSA-N.
Keywords: | N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-glycine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 9002300 |
Properties
Application: | Thrombin inhibitor, active ximelagatran metabolite |
MW: | 429.5 D |
Formula: | C22H31N5O4 |
Purity: | >90% |
Format: | Solid |
Database Information
CAS : | 159776-70-2| Matching products |
KEGG ID : | K01313 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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