MDL 29951

NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.Formal Name: 2-carboxy-4,6-dichloro-1H-indole-3-propanoic acid. CAS Number: 130798-51-5. Molecular Formula: C12H9Cl2NO4. Formula Weight: 302.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 309 nm. SMILES: ClC1=CC(Cl)=C(C(CCC(O)=O)=C(C(O)=O)N2)C2=C1. InChi Code: InChI=1S/C12H9Cl2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19). InChi Key: KNBSYZNKEAWABY-UHFFFAOYSA-N.