MCI-INI-3

MCI-INI-3 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3, Ki = 0.55 µM). It is selective for ALDH1A3 over ALDH1A1 (Ki = 78.2 µM). MCI-INI-3 (15 µM) inhibits the conversion of retinol to retinaldehyde in U87MG glioblastoma cells. It reduces the viability of GSC-83 and GSC-326 glioblastoma cells when used at a concentration of 15 µM.Formal Name: 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylic acid, methyl ester. CAS Number: 1011366-31-6. Molecular Formula: C21H15N3O4. Formula Weight: 373.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC. InChi Code: InChI=1S/C21H15N3O4/c1-26-21(25)17-10-15(14-7-8-18-19(9-14)28-12-27-18)22-20-11-16(23-24(17)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3. InChi Key: DCSWTUKGGUNNLU-UHFFFAOYSA-N.