MCC950 . Na

MCC950 . Na
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CR1-3615-M001 1 mg -

3 - 9 business days*

39.00€
AG-CR1-3615-M005 5 mg -

3 - 9 business days*

72.00€
AG-CR1-3615-M010 10 mg -

3 - 9 business days*

121.00€
AG-CR1-3615-M050 50 mg -

3 - 9 business days*

462.00€
 
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol... more
Product information "MCC950 . Na"
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production of IL-1beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). Also active in ex vivo samples from individuals with Muckle-Wells syndrome. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
Keywords: MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CR1-3615

Properties

Application: NLRP3 inflammasome inhibitor
MW: 426,5 D
Formula: C20H23N2NaO5S
Purity: >98%
Format: Solid

Database Information

CAS : 256373-96-3| Matching products
KEGG ID : K12800 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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