Mavorixafor

Mavorixafor is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50 = 13 nM in a radioligand binding assay). It is selective for CXCR4 over chemokine (C-C motif) receptor 1 (CCR1), CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all). Mavorixafor reduces chemotaxis of CCRF-CEM T cells induced by chemokine (C-X-C motif) ligand 12 (CXCL12, IC50 = 19 nM). It inhibits fusion of CHO-K1 cells expressing gp120 to P4-P5 MAGI cells with an IC50 value of 1.5 nM. It decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 2 and 9 nM, respectively).Formal Name: N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine. CAS Number: 558447-26-0. Synonyms: AMD 070, AMD 11070, X4P-001. Molecular Formula: C21H27N5. Formula Weight: 349.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 270, 277 nm. SMILES: NCCCCN(CC1=NC2=C(C=CC=C2)N1)[C@@H]3C4=NC=CC=C4CCC3. InChi Code: InChI=1S/C21H27N5/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15,22H2,(H,24,25)/t19-/m0/s1. InChi Key: WVLHHLRVNDMIAR-IBGZPJMESA-N.