Matairesinol

Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities. It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) in RAW 264.7 cells. Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml). It increases the lifespan of C. elegans when used at a concentration of 100 µM. Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Cay-13106). Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.Formal Name: dihydro-3R,4R-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone. CAS Number: 580-72-3. Synonyms: (-)-Matairesinol. Molecular Formula: C20H22O6. Formula Weight: 358.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 230, 282 nm. SMILES: OC1=C(OC)C=C(C[C@@H]2[C@@H](CC3=CC(OC)=C(O)C=C3)COC2=O)C=C1. InChi Code: InChI=1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1. InChi Key: MATGKVZWFZHCLI-LSDHHAIUSA-N. Origin: Synthetic.