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Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals. MBG inhibits the ouabain-resistant alpha1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension. Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure. Through its effects on the alpha1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.Formal Name: (3beta,5beta,15beta)-14,15-epoxy-3,5-dihydroxy-bufa-20,22-dienolide. CAS Number: 470-42-8. Synonyms: Marinobufagin, MBG, NSC 234205. Molecular Formula: C24H32O5. Formula Weight: 400.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 297 nm. SMILES: O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O5)[C@H]5C[C@@H]4C6=COC(C=C6)=O)(O)C1. InChi Code: InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1. InChi Key: JMNQTHQLNRILMH-OBBGIPBRSA-N.
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