Magnolin

Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities. It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC50 = 20.5 µM). Magnolin inhibits ERK1 and ERK2 (IC50s = 87 and 16.5 nM, respectively) and EGF-induced NF-kappaB transactivation activity when used at concentrations of 30 and 60 µM. It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells. It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 µM. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 µmol/kg.Formal Name: (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan. CAS Number: 31008-18-1. Synonyms: (+)-Magnolin. Molecular Formula: C23H28O7. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 231, 278 nm. SMILES: COC(C=C1)=C(OC)C=C1[C@@H](OC2)[C@]3([H])[C@@]2([H])[C@@H](C4=CC(OC)=C(OC)C(OC)=C4)OC3. InChi Code: InChI=1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3/t15-,16-,21+,22+/m0/s1. InChi Key: MFIHSKBTNZNJIK-RZTYQLBFSA-N.