Mafenide

Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria. It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 µg/ml. Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum beta-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 µg/ml, 1,024 µg/ml, and 1,024 µg/ml, respectively). It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa. Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 µM, respectively). Formulations containing mafenide have been used in the treatment of severe burns.Formal Name: 4-(aminomethyl)-benzenesulfonamide. CAS Number: 138-39-6. Synonyms: NSC 34632. Molecular Formula: C7H10N2O2S. Formula Weight: 186.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: slightly soluble. lambdamax: 224 nm. SMILES: NCC1=CC=C(S(N)(=O)=O)C=C1. InChi Code: InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11). InChi Key: TYMRLRRVMHJFTF-UHFFFAOYSA-N.